The Cellular Energy Profile evaluates organic acids that play a pivotal role in the generation of cell energy. The test can reveal metabolic distress associated generalized pain and fatigue, which may arise in response to toxic exposure, nutrient imbalances, digestive dysfunction and other causes.
Plants synthesize and store energy from sunlight and nutrients. How efficiently the human body recovers this energy from plants or animals that eat plants can have a profound effect on physiological function. Fundamentally, optimal health and well-being depends on the healthy functioning of the cell. The mitochondria of each cell functions as its energy "factory." The primary function of the mitochondria is to efficiently produce the energy we require to live vital lives.
The Cellular Energy Profile measures a special grouping of organic acids. These metabolites primarily reflect carbohydrate metabolism, mitochondrial function, and oxidation of fatty acids that occurs during cellular respiration. The organic acids measured in this panel are central components or intermediates in metabolic pathways of energy conversion related to the Kreb (citric acid) cycle and the production of ATP-the cell's main fuel source.
Defects of mitochondrial metabolism are associated with a wide spectrum of illness and disease. This test can reveal metabolic distress that can arise from toxic exposure, nutrient deficiency, intestinal dysbiosis, dysglycemia, oxidative stress, poor diet, and other causes. The profile is particularly relevant for the chronically "unwell" patient, who may be experiencing multiple chemical sensitivities, fibromyalgia, fatigue, malaise, hypotonia (loss of muscle tone), acid-base imbalance, low exercise tolerance, muscle/joint pain, or headache.
Organic acids also play a pivotal role in generating energy for muscle tissue. For this reason, mitochondrial defects are associated with a variety of neuromuscular disorders. Imbalances may also influence cardiac function, glycemic control, and behavior. Moreover, because the mitochondria modulate cell death, their dysfunction is closely linked with the aging process and neurodegenerative diseases like Alzheimer's, Parkinson's and ALS.
This test serves as a diagnostic aid for acquired, as opposed to in-born, errors of organic acid metabolism. Each analyte is reported in relation to creatinine levels to ensure normal renal function and representative results. Significantly abnormal findings may be due to inborn errors if they persist after removal of toxics, nutrient supplementation, dietary adjustments, and correction of intestinal dysbiosis or infection. For these cases, further specialized follow-up testing is needed to identify congenital organic acidopathies.
What You Should Know
This test reveals important clinical information about:
Thirteen organic acids that specifically reflect carbohydrate metabolism, mitochondrial function, and beta-oxidation of fatty acids
Mitochondrial dysfunction which may be underlying chronic symptoms of fibromyalgia, fatigue, malaise, hypotonia (loss of muscle tone), acid-base imbalance, low exercise tolerance, muscle/joint pain, or headache
Acquired errors of organic acid metabolism that can arise from toxic exposure, nutrient deficiency, intestinal dysbiosis, dysglycemia, oxidative stress, poor diet, and other causes.
Specimen Requirement:
First early morning urine collection
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